Biochemistry & Pharmacology: Open Access
Open Access

Zhang Lun

Publications

• Review Article
  The Role of miRNAs Playing in Human Cancers Chemosensitivity
  Author(s): Zhang Lun, Liu Ai-Qin and Zhou XuanZhang Lun, Liu Ai-Qin and Zhou Xuan
  
  Malignant carcinoma is one of the most threatening diseases to our human being’s life and health. However, chemotherapy, as one of the principal modes of treatment, especially for metastatic cancers, has been blocked by drug resistance, which contributing to disease progression and leading to a high mortality rate. Thus, research on both mechanisms and resolutions to chemo resistance seems extremely indispensable and urgent. MicroRNAs (miRNAs), the recently emerging class of novel molecules, have been reported to have close correlation with cancer. They act as oncogene or tumor suppressor gene, and growing evidence indicates that the desregulation of miRNAs involves in drug resistance. Alteration of miRNA’s expression leads to obviously different responsiveness to anticancer drugs. It implicates that miRNA may be a promising therapeutic target for improvement of chemoresis.. View More»
  DOI: 10.4172/2167-0501.1000133

  Abstract PDF

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