Biochemistry & Pharmacology: Open Access
Open Access

Zhang Y

Publications

• Research Article
  Antibacterial Activity and Cytotoxicity of Gold (I) and (III) Ions and Gold Nanoparticles
  Author(s): Shareena Dasari TP, Zhang Y and Yu HShareena Dasari TP, Zhang Y and Yu H
  
  Gold nanoparticles (AuNPs) and gold ion complexes have been investigated for their antibacterial activities. However, the majority of the reports failed to disclose the concentration of free Au(I) or Au(III) present in solutions of AuNPs or gold ion complexes. The inconsistency of antibacterial activity of AuNPs may be due to the effect of the presence of Au(III). Here we report the antibacterial activity of Au(I) and Au(III) to four different bacteria: one nonpathogenic bacterium: E. coli and three multidrug-resistant bacteria: E. coli, S. typhimurium DT104, and S. aureus. Au(I) and Au(III) as chloride are highly toxic to all the four bacteria, with IC50 of 0.35 - 0.49 μM for Au(III) and 0.27-0.52 μM for Au(I).The bacterial growth inhibition by both Au(I) and Au(III) increases with exposure time and is strongly affected by the use of buffers. The IC.. View More»
  DOI: 10.4172/2167-0501.1000199

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