Journal of Developing Drugs
Open Access

Zhao Qing

Publications

• Research Article
  Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets
  Author(s): Himankar BaishyaHimankar Baishya
  
  The aim of present work is to determine and analyse the kinetics of drug release from the matrix tablet by employing various mathematical models. A study was done with Carbidopa and Levodopa ER tablets, 50 mg/200 mg by employing wet granulation technique using Hydroxypropyl methylcellulose and Hydroxypropyl cellulose as matrix forming polymer. The in-vitro drug release profile was carried out in 0.1 N HCl (900 mL) using USP dissolution apparatus II (Paddle) at 50 rpm at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coeff.. View More»
  DOI: 10.4172/2329-6631.1000171

  Abstract PDF

Relevant Topics