Advanced Techniques in Biology & Medicine
Open Access
ISSN: 2379-1764
ISSN: 2379-1764
Zhongfei Han
China
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Aromatic Heterobicyclics-Based Design of Aldose Reductase Inhibitors as Drug Candidates for the Treatment of Diabetic Complications
Author(s): Zhongfei Han, Nino Rcheulishvili, Dimitri Papukashvili, Xin Hao and Changjin Zhu
Zhongfei Han, Nino Rcheulishvili, Dimitri Papukashvili, Xin Hao and Changjin Zhu
Aldose reductase (ALR2) plays a pivotal role in the development of diabetic complications. ALR2 inhibitors (ARIs) have proven efficient to prevent and delay the chronic diseases, and thus attracted significant research interest. This article reviews a series of aromatic heterobicyclics-based ARIs developed over recent years, and discusses about their structure-activity relationships as well as their multifunctionalities such as antioxidant property
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DOI:
10.4172/2379-1764.1000152