ISSN: 2155-9554
+44 1478 350008
Department of Dermatology, Hamad Medical Corporation, Doha, Qatar
A M Al-Obaidli is Hamad Medical Corporation | HMC. His research interests includes Autoimmune bullous disease. He/ She has successfully completed his Administrative responsibilities. He /she has authored of many research articles/books related to Autoimmune bullous disease.
Case Report
Successful Treatment of Epidermolysis Bullosa Pruriginosa with Anti-IgE Therapy (Omalizumab): A Case Report and Four Years Follow Up
Author(s): S A Taha*, M A Al-Nesf and A M Al-Obaidli
Importance: Epidermolysis bullosa pruriginosa (EBP) is a rare adult-onset heredo-familial skin disorder. Bullous skin
lesions are triggered by intense pruritus, which is the hallmark of the disease. Eosinophilic infiltrates and elevated IgE
levels in serum and lesions have been reported, but their pathological role is yet to be determined. Although
treatment with anti-IgE therapy (Omalizumab) has been used successfully in autoimmune bullous diseases but not in
EBP to our knowledge.
Observation: We report a case of a 34-year-old female with adult-onset pruritic and blistering disease of the skin. Sub
epidermal blisters with viable roofs and numerous epidermal neutrophils and eosinophilic infiltrate were detected
histopathologically; however, the absence of IgA, IgG, IgM, C1q, and C3 deposits made the diagnosis of
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DOI:
10.35248/2155-9554.20.11.520