Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Pediatrics, University of California San Francisco, San Francisco, USA
Dr. Kornblith is an Associate Professor of Emergency Medicine and Pediatrics at the University of California San Francisco. He is Director of Pediatric Emergency Ultrasound for the UCSF Benioff Children’s Hospital San Francisco. His research program is focused on improving the diagnostic evaluation of the sick and injured child through advanced data analytics and novel hardware design.
Research Article
Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples
Author(s): Won Lee, Steven Straube, Ryan Sincic, Jeanne A. Noble, Juan Carlos Montoy, Aaron E. Kornblith, Arun Prakash, Ralph Wang, Roland J. Bainton and Philip A. Kurien*
Introduction: The SARS-CoV-2 pandemic has spurred the development of numerous Point of Care (POC)
immunoassays. Previous studies assessing performance of these available kits occurred in a laboratory setting, raising
concerns of translating findings for POC use. We aim to assess the performance of a lateral flow immunoassay for the
detection of SARS-CoV-2 antibodies using samples collected at POC.
Method: One lateral flow immunoassay (Humasis® COVID-19 IgG/IgM) was tested. Fifty PCR RT-PCR positive and
52 RT-PCR negative samples were collected at POC. Fifty Pre-Covid serum specimens were used as controls. Clinical
data including symptom onset date was collected from patient history and the medical record.
Results: The overall sensitivity for the kit was 74% (95% CI: 59.7%-85.4%). The sensi.. View More»
DOI:
10.4172/2167-7964.1000324