Journal of Pharmaceutical Care & Health Systems
Open Access

Department of Internal Medicine, University of Hospital Centre Mother Teresa, Rruga e Dibres, Tirana AL, Albania

Publications

• Case Report   
  Long-Term Clozapine Treatment and Chronic Lymphocytic Leukemia: A Case Report
  Author(s): Adela Perolla*
  
  Background: Clozapine is an a typical antipsychotic drug, without extrapyramidal side effects, showing potential for the treatment of resistant forms of schizophrenia, which affects approximately 30% of patients diagnosed with this disease. The risk of agranulocytosis encountered in patients using clozapine is not the only reason that psychiatrists hesitate. Moreover has been observed a correlation between clozapine use and the development of lymphomas and even acute leukemia in some patients. We present a 47-years-old patient diagnosed with Treatment-Resistant Schizophrenia (TRS) on clozapine medication for almost eight years, who developed Chronic Lymphocytic Leukemia (CLL). We also performed a literature review using the pubmed database regarding the hematological malignancy induced effects of clozapine in long-term treatment-resistant .. View More»
  DOI: 10.35248/2376-0419.23.10.265

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