Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Nursing, Stevens Institute of Technology, Hoboken, USA
Research Article
Identification and Analysis of Molecular Pathways and Key Candidate Biomarkers in Glioblastoma Multiforme
Author(s): Aditi Stuti Kumari*
Glioblastoma Multiforme (GBM) is a Grade IV malignant primary tumor present in the central nervous system.
Despite advancements in treatments, it has a poor prognosis as the median survival is 14 months-15 months. The
goal of this study was to identify the candidate biomarkers as well as the functional pathways regulated in GBM. The
dataset (GSE100675) accessed included 3 glioblastoma tissues, 3 paired tissues, and 3 normal tissues. The
Differentially Expressed Genes (DEGs) were identified using GEO2R, which found a total of 1,609 DEGs (916
downregulated and 693 upregulated). A gene ontology and KEGG pathway analysis was done with the DEGs. The
KEGG pathway analysis was then utilized in constructing a Protein Protein Interaction (PPI) network, identifying the
genes of interest. The interaction network was then put into cytoscape and 10 hub genes were identified. T.. View More»
DOI:
10.35248/2167-0870.23.13.525