Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil
Research Article
Differential Behavior of Bone Turnover Markers in Women with Bone Metastatic Breast Cancer or Osteoporosis
Author(s): Ana Laura Soares*, Jose Gilberto Henrique Vieira, Linda Denise Fernandes Moreira, Andre Goncalves da Silva, Marise Lazaretti Castro, Sergio Daniel Simon, Luiz Henrique Gebrim and Afonso Celso Pinto Nazario
Background: This study was designed to describe Bone Turnover Marker (BTM) profiles in women.
Patients and methods: In all, 197 patients (age 61 (36-90) years) comprising five groups were studied: Osteoporosis with (OPBP+) or without (OPBP-) bisphosphonate use; bone metastatic breast cancer with (BMBP+) or without (BMBP-) BP use; and healthy controls without BP (CBP-) use. Procollagen type 1 amino-terminal Propeptide (P1NP) and Carboxy-terminal Telopeptideof type 1 collagen (CTX) wereanalyzed.
Results: The medians (25%-75%; ng/mL) for P1NP were as follows: BMBP (236.95(165.0-328.0))> CBP(47.25(33.5-63.7))=OPBP-(50.9(37.4-63.9))>BMBP+(26.9(11.8-46.3))=OPB+(19.5(12.6-27.3)). The medians (25%-75%; ng/mL) for CTX wereas follows: BMBP-(0.567(0.457-0.803))=OPBP-(0.360(0.318-0.650))>CBP-(0.297(0.203-0.402))>BM.. View More»
DOI:
10.35248/2167-0870.23.13.271