Journal of Nutrition & Food Sciences
Open Access

Ministry of Education and Sports-Junta d, Delegation of Education, Juan Antonio de Vizarrón, Spain

Publications

• Review Article   
  P53 Protein Modulates Muscle Metabolism and Generates a Non-genetic Risk Environment that Contributes to Triggering Amyotrophic Lateral Sclerosis
  Author(s): Agueda Gema Espina-Zambrano*
  
  Amyotrophic lateral sclerosis (ALS) is also called "motor neuron disease”. In this review, we propose that ALS is not just a neuromotor disorder, but begins as a disorder of P53- modulated skeletal muscle metabolism, leading to failures at the energy state of the cells, incorrect redox states, motor denervation, and a loss of muscle fibers. Motoneurons die as a consequence of the lack of muscular feedback, and the oligomeric TDP43 aggregates progressively and relentlessly lead to mistakes in peripheral immune self-tolerance sustained over time. An effective treatment has not been found for this devastating pathology, as for 152 years the target has not been accurately defined. Scientists and doctors should consider new knowledge regarding ALS and consider immunomodulatory therapies that, based on genetic analysis and symptoms, can be combined with compounds that regulate me.. View More»
  DOI: 10.35248/2155-9600.22.12.1000834

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