Journal of Drug Metabolism & Toxicology
Open Access

Department of Pharmacokinetics, Doshisha Women's College of Liberal Arts, Kyoto, Japan

Publications

• Research Article   
  Pharmacokinetic-Pharmacodynamic Analyses of the Antidiabetic Drug, Nateglinide, in Goto-Kakizaki Rats Based on Pharmacological Mechanism
  Author(s): Akiko Kiriyama*, Shunsuke Kimura and Shugo Yamashita
  
  Background: Quantitative understanding of the Pharmacokinetics (PK) and pharmacological effects/side effects of antidiabetic drugs is important for preventing serious complications. We investigated the PK of nateglinide, a rapid and short-lived insulin release model drug, in type 2 diabetes model rats, analysing the time profiles of plasma insulin and glucose levels. Using PK and Pharmacodynamics (PD) analysis, we quantitatively investigated relationship between nateglinide PK and its PD. Methods: Nateglinide was administered to rats, and blood samples were subsequently collected for PK, insulin, and glucose analyses. PK and PK-PD model analyses of nateglinide were then performed. Results: The 3-compartment model exhibited slightly better at low plasma concentrations compared to the 2-compartment model. However, lo.. View More»
  DOI: 10.35248/2157-7609.24.15.330

  Abstract HTML PDF