Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Pediatrics and Adolescent Medicine, Juntendo University School of Medicine Graduate School of Medicine, Tokyo, Japan
Research Article
Role of IL-1RL1/ST2 in Infantile Asthma
Author(s): Yosuke Baba*, Akina Matsuda, Yuri Takaoka, Kazuki Miyabayashi, Hiromichi Yamada, Toshiyuki Yoneyama, Susumu Yamazaki, Eisuke Inage, Yoshikazu Ohtsuka, Masato Kantake and Toshiaki Shimizu
Background: Wheezing is the dominant pathological characteristic of asthma. It is estimated that 50% of all children have experienced wheezing at least once in their first six years of life. In the present study, we aimed to investigate the initial wheezing attacks of children and to determine whether there was a connection between transient wheezing attacks and persistent wheezing.
Methods: We studied the immune responses of children who initially presented with wheezing attacks. A total of 231 children with wheezing attacks at the time of admission were enrolled in the study. The study population consisted of 68 children with wheezing episodes. Children with recurrent wheezing who were introduced to inhale steroids after 12 months were further grouped into either persistent wheezing (PW) or transient wheezing (TW) groups.
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