ISSN: 2157-7609
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Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ekiti State, Nigeria
Research Article
Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats
Author(s): Akintayo C.O, Olukiran O.S*, Ayodele M.J and Karga S.V
Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and
prevalence of use continues to grow.
Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats.
Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5
rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of
cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA.
Results: The serum concentrations of AST and ALT were significantly higher in groups 3, 4 and 5 when compared
with groups 1 and 2. Groups 1 and 2 had LDL and HDL that were significantly lower than that of groups 3 and 4.
Rats in group .. View More»
DOI:
10.35248/2157-7609.23.14.271