ISSN: 2169-0138
Biology Research Department, Academies of Loudoun in Ashburn, Virginia, United States
Research
A Molecular Docking Approach to the Drug Inhibition of Endothelial Cell Adhesion Molecules Associated with Small Cell Lung Cancer Progression
Author(s): Akshay P. Kulakarni*
Small Cell Lung Cancer (SCLC) is a multistage, aggressive, metastatic form of lung cancer that accounts for about
13% of all lung cancer cases, with a 5-year survival rate of less than 6% mainly due to its metastatic component. The
focus of metastatic SCLC has been focused on inhibiting the communication between SCLC circulating tumor cells
and Cell Adhesion Molecules (CAMs) on endothelial cells, which cancer cells utilize to facilitate transmigration into
a secondary tissue site after detaching from the primary tumor. It is well known that multiple CAMs are involved in
SCLC transmigration; however, due to the different structures of CAM superfamilies involved in communication,
efficient inhibitors to multiple CAMs have not been recognized. This study presents an in silico, molecular
modeling approach to find potent inhibitors to multiple cell adhesion molecules i.. View More»
DOI:
10.35248/2169-0138.21.10.e187