Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Internal Medicine, San Giovanni di Dio Hospital, Florence, Italy
Research Article
Retrospective Multicenter Study of COVID-19 Patients Admitted to Non-ICU Wards during the Omicron (B.1.1.529) Variant Surge: Assessment of Clinical Characteristics and Outcomes by Vaccination Status
Author(s): Antonio Faraone*, Giulia Scocchera, Tommaso Picchioni, Francesca Palandri, Gabriele Nenci, Elisa Grifoni, Luca Masotti, Alessandro Morettini and Alberto Fortini
Background: The benefits of prior vaccination in patients hospitalized for moderate to severe COVID-19 during the Omicron surge are not well defined. We assessed characteristics and outcomes of a cohort of COVID-19 inpatients by their vaccination status.
Methods: Patients admitted with moderate to severe COVID-19 between December 20, 2021 and March 31, 2022 were divided into 3 groups: 1) unvaccinated, 2) vaccinated with 2 doses, and 3) vaccinated with 3 doses. The main outcome was a composite of ICU transfer, mechanical ventilation or in-hospital death (poor outcome).
Results: We enrolled 446 patients (median age 78 years, IQR 65-85.3), of which 168 (37.7%) unvaccinated, 113 (25.3%) vaccinated with 2 doses and 165 (37%) vaccinated with 3 doses. Vaccinated patients had a higher comorbidity burden and were older (3-d.. View More»
DOI:
10.35248/2471-9552.23.09.221