Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Cellular and Immunology, CMH Research and Innovation Bolaram, Secunderabad, Telangana, India
Research Article
Differential Expression Analysis of Natural Killer (NK) Cell Receptor (NKG2D) in Hepatitis C Virus-Infected Chronic Hepatitis and Hepatocellular Patients for the Development of Targeted Immunotherapy
Author(s): Roya Rozati*, Vikram Aiman Ayapati, Gautam Mehdi Ayapati and Aleem Ahmed Khan
Background: Hepatitis C Virus (HCV) infection causes liver cell injury and ultimately results in liver cirrhosis, fibrosis, and further HCC. Despite current treatment strategies using Direct-Acting Anti-virals (DAAs) to treat HCV patients 40% of HCV infection leads to the development of HCC. The Natural killer cells have a crucial role in an immune response against malignant transformation, including hepatocellular carcinoma. As Natural Killer (NK) cells constitute 25%-50% of liver lymphocytes, they have a significant role to play in liver immunity. A positive correlation exists between the number of Natural Killer (NK) cells in the blood and tumor tissues of HCC patients and their survival and prognosis. The NKG2D receptor has a critical role in the Natural Killer (NK) recognition of target cells. Among different mechanisms, Natural Killer (NK) cell-based innate immu.. View More»
DOI:
10.35248/2471-9552.23.09.235