Gynecology & Obstetrics
Open Access

Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, India

Publications

• Research Article   
  Impact of Mitochondrial Oxidative Phosphorylation Dysfunction in the Patient with Endometriosis
  Author(s): Roya Rozati*, Aleem Ahmed Khan, Wajeeda Tabasum, Salwa Sahar Azimi, Vikram Aiman Ayapati, Ayapati Gautam Mehdi, Nasaruddin Khaja, Krishnan Sivaraman and Sripriya Vennamaneni
  
  Background: Endometriosis is a chronic inflammatory condition where the precise cause of endometriosis is still not unclear. Mitochondrial dysfunction has been reported in severe forms of endometriosis. However, the role of mitochondrial dynamics, mitophagy, and mitochondrial-related complexes in endometriosis and its relation with Epithelial-Mesenchymal Transition (EMT) is not clear. Objective: Therefore, this study aims to elucidate the role of mitochondrial dysfunction and its relation with EMT in the pathogenesis of endometriosis. Material and methods: At present, cell viability, immunophenotypic enrichment using flow cytometry, and gene expression by real-time quantitative PCR were carried out. Results: A significant decrease in the expression of OXPHOS genes, DRP1, Pink-1, Parkin, and E-cadh.. View More»
  DOI: 10.35248/2161-0932.24.14.4.621

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