Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Department of Medical Biotechnologies, University of Siena, Siena, Italy
Research Article
Prevention Strategies in Patients affected by Actinic Keratosis of the Head: A 12-Month, Prospective, Assessor-Blinded, Controlled Study with Lesion-Directed Treatment Associated with Medicalized Photoprotection
Author(s): Arianna Lamberti, Alessandra Cartocci, Carolina Donelli, Giulio Cortonesi, Emanuele Trovato, Massimo Milani*, Pietro Rubegni and Elisa Cinotti
Objective: We assessed the efficacy of a 100+SPF sunscreen containing DNA-repairing enzymes (endonuclease,
glycosylase, and photolyase) and a potent antioxidant extract (Polypodium Leucotomos Extract: PLE) (“Medicalized”
Photoprotection: MP), in subjects with Actinic Keratosis (AK) treated with cryotherapy measuring the evolution of
AKASI score and through a non-invasive analysis with Line-field Confocal-Optical Coherence Tomography (LC)-
OCT.
Patients and Methods: A prospective, 12-month, assessor-blinded, controlled study enrolling patients with ≤ 5 actinic
keratoses on the face and/or scalp suitable for cryotherapy was performed. After cryotherapy, 30 subjects were
instructed to apply the MP twice daily for 12 consecutive months. Thirty subjects were selected as a control group.
AKASI score was evaluated .. View More»
DOI:
10.35841/2329-9509.22.13.620