Journal of Infectious Diseases & Preventive Medicine
Open Access

Perm State Medical University, Perm, Russian Federation

Biography

Dr. Alevtina Nicolaeva is a distinguished researcher and academic affiliated with Perm State Medical University in Perm, Russia. Her work primarily focuses on immunology, vaccine development, and infectious diseases, contributing significantly to advancements in these fields.Dr. Nicolaeva's research centers on: Development and enhancement of influenza vaccines. Evaluation of adjuvants to improve vaccine efficacy. Preclinical and clinical studies on vaccine safety and immunogenicity.

Publications

• Research Article   
  TetraFluBet: A Tetravalent Influenza Vaccine Enhanced with Natural Betulin Adjuvant
  Author(s): Irina Tcymbarevich, Anna Krasheninnikova, Maria Sukhova, Aleksandr Ivanov, Marina Stukova, Ekaterina Romanovskaya-Romanko, Nataliya Mikhailova, Anton Belkin, Olga Belyakova, Alevtina Nicolaeva and Igor Krasilnikov*
  
  Influenza is well-known to have a considerable influence on the healthcare system; therefore, vaccination plays a significant role in dealing with severe consequences. Close attention is paid to the development of tetravalent adjuvanted vaccines containing antigens of two influenzas A subtypes (H1N1, H3N2) and two influenza B subtypes (Victoria, Yamagata) to increase the effectiveness of influenza prevention. In this work, we present the results of an animal study of an innovative subunit tetravalent candidate influenza vaccine with the addition of betulin as an adjuvant, TetraFluBet. The study was conducted using female BALB/c mice, male and female mongrel rats, and guinea pigs. TetraFluBet was injected intraperitoneally twice in a 14-day interval prior to intranasal infection with 100LD50. Sub-chronic toxicity was assessed by immunohistochemistry of extracted organs and by hematolog.. View More»
  DOI: 10.35841/2329-8731.24.12.371

  Abstract HTML PDF

Other relevant publications from this author

• https://www.longdom.org/open-access-pdfs/tetraflubet-a-tetravalent-influenza-vaccine-enhanced-with-natural-betulin-adjuvant.pdf?utm_source=chatgpt.com

  https://erj.ersjournals.com/content/54/suppl_63/PA1009?utm_source=chatgpt.com