ISSN: 2167-1044
Department of Psychiatry, Psychotherapy and Psychosomatics, Hospital Herford, Herford, Germany
Research
Acute Anxiolytic Effects of Sacubitril/Valsartan in Patients with Heart Failure
Author(s): Michael Kellner*, Alexander Yassouridis, Dominik Górski, Saddoff Waheed, Jan Kähler and Klaus Wiedemann
Objective: Anxiety is a frequent symptom in Heart Failure with Reduced Ejection Fraction (HFrEF). By inhibition of
the endopeptidase neprilysin, Sacubitril/Valsartan (S/V) blocks degradation of Atrial Natriuretic Peptide (ANP),
which has anxiolytic-like effects in man. In patients suffering from HFrEF we presumed an acute anxiolytic action of
S/V and its mediation via ANP.
Methods: 56 patients with decompensated HFrEF were treated with S/V (24 mg/26 mg b.i.d.) or Treatment As
Usual (TAU) without S/V in an open, non-randomized observational pragmatic controlled trial. At days 0 and 7,
anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS) and plasma levels of ANP and heart
failure biomarker N-Terminal pro B-type Natriuretic Peptide (NT-proBNP) were measured.
Results: 35 pa.. View More»
DOI:
10.35248/2167-1044.23.12.499