Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran
Review Article
Identification of Electrochemical Immunosensors for Neurological Diseases by BDNF and NfL
Author(s): Saeid Charsouei*, Ahmad Mobed*, Yalda Yazdani, Morad Kohandel Gargari, Ali Ahmadalipour, Seyyedeh Reyhaneh Sadremousavi, Maryam Farrahizadeh, Ali Shahbazi and Maryam Haghani
Key biomarkers such as BDNF (Brain-derived Neurotrophic Factor) and NfL (Neurofilament Light Chain) play
important roles in the development and progression of many neurological diseases, including multiple sclerosis,
Alzheimer's disease and Parkinson's disease. In these clinical conditions, the underlying biomarker processes are
markedly heterogeneous. In this review, robust biomarker discovery is of critical importance for screening, early
detection, and monitoring of neurological diseases. The difficulty of directly identifying biochemical processes in
the Central Nervous System (CNS) is challenging. In recent years, biomarkers of CNS inflammatory response have
been identified in various body fluids such as blood, cerebrospinal fluid, and tears. Furthermore, biotechnology
and nanotechnology have facilitated the development of biosensor platforms capable of real-.. View More»
DOI:
10.35248/JCCLM.23.6.264