Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
We performed genetic studies in 36 members of a large, consanguineous five-generation family, in which 4 members had recurrent fungal infections and an additional 3 members died during adolescence, 2 after invasive infection of the brain with candida species. All 36 family members were enrolled in the study, and 22 had blood samples taken for DNA analysis. Homozygosity mapping was used to locate the mutated gene.
Research Article
Cell Therapy in Transplantation
Author(s): Aliakbar Amirzargar*, Amir Hossein Mansourabadi and Sara Bahramkiya
Organ transplantation is an established and practical definitive treatment option for patients with end-stage organ
dysfunction. Unlike improvements in short-term graft survival, long-term graft survival is the main challenge due to
the increased morbidity and mortality associated with the toxicity of immunosuppressive regimens and chronic
rejection. Since a novel therapeutic strategy to fulfill allograft tolerance seems urgent, the attention of the transplant
community is focusing on the development of the new safe approach to prolong graft survival. Various researches
have focused on immune regulation in the context of organ transplantation with mesenchymal stem cells and
regulatory T cells (Tregs) identified as cells that have the potential to suppress or optimize the immune responses in
different situations. In this review article, we will provide an overview.. View More»