Poultry, Fisheries & Wildlife Sciences
Open Access
ISSN: 2375-446X
+44-77-2385-9429
ISSN: 2375-446X
+44-77-2385-9429
Department of Molecular and Cellular Medicine, College Station, Texas A&M University Health Science Center, TX 77843, USA
Research Article
Bacillus anthracis Sterne Strain 34f2 Vaccine Antibody Dose Response by Subcutaneous and Oral Administration
Author(s): Jamie Benn Felix*, Sankar P Chaki, Thomas A Ficht, Allison C Rice-Ficht and Walt Cook
Anthrax (Bacillus anthracis) is a zoonotic disease endemic to environments worldwide. Spores, the dormant form of the bacteria, can survive for decades in nature’s harshest environments and maintain their viability to cause disease. Outbreaks are common in free-ranging livestock and wildlife, thus making anthrax an economically and ecologically important disease. The currently available vaccine to protect livestock is a suspension of B. anthracis Sterne Strain 34F2 spores in saponin (Sterne vaccine). However, it is only available as a subcutaneous injection which is an impractical method of prevention for wildlife. Oral vaccination is the ideal method for free-ranging wildlife, but the Sterne vaccine has never been thoroughly evaluated for oral administration. The current study evaluated the antibody titers induced in mice by subcutaneous or oral vaccination with three different.. View More»
DOI:
10.35248/2375-446X.19.7.206