Journal of Clinical and Cellular Immunology
Open Access

Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu State, Nigeria

Biography

Alphonsus Ogbonna Ogbuabor is working in faculty of Health Sciences and Technology at University of Nigeria which is located in Nigeria.
Globally, hemoglobinopathies remains a common genetic disorder of blood with highest prevalence recorded in the developing countries particularly those of the sub-Saharan Africa

Publications

• Review Article   
  The JAK-STAT Signaling Pathway: A Novel Therapeutic Target for Unexplained Recurrent Implantation Failures
  Author(s): Alphonsus Ogbonna Ogbuabor*, Peter Uwadiegwu Achukwu, Daniel Chukwuemeka Ogbuabor, Silas Anayo Ufelle and Rapheal Chinweike Okolo
  
  Unexplained recurrent implantation failure has become a public health problem especially in the context of a high cost, demand for assisted reproductive therapy and multiple therapy failures. It is attributed to the failure of immunological tolerance between the transferred embryo and the endometrium during assisted reproductive therapy cycles. Cytokines are surrogate mediators of immunological tolerance mechanisms. Since the synergistic interaction between individual cytokines is dynamic, perturbations in the cytokine crosstalk during embryo implantation is considered a major etiology for unexplained recurrent implantation failures. Genome Wide Association Studies suggests that most cytokines initiate their actions through receptor interactions that activate the JAK-STAT signaling pathways. Aberrations in the JAK-STAT signaling pathways have as well been shown to.. View More»
  DOI: 10.35248/2155-9899.20.11.587

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