Journal of Clinical Toxicology
Open Access

Division of Otolaryngology, St. Paul's Sinus Centre, University of British Columbia, Vancouver, Canada

Biography

Dr. Amin Javer, Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio (MJC); University of British Columbia, Vancouver, British Columbia, Canada (ARJ); and the Georgia Rhinology and Sinus Center, Savannah, Georgia (FAK)

Publications

• Research Article   
  In vitro Inactivation of SARS-Cov-2 by Povidone-Iodine In situ Gel Forming Solution
  Author(s): Bo Liang*, Xudong Yuan, Gang Wei, Wei Wang, Ming Zhang, Haizhou Peng, Juan C. Hernaiz-Leonardo, Amin Javer, Michelle Mendenhall, Justin Julander, Sammi Huang, Hany Michail, Yong Lu, Qi Zhu and John Baldwin
  
  Background: Povidone Iodine (PVP-I) nasal solutions are effective against the SARS-CoV-2 virus, but are cleared rapidly from the nasal cavity, limiting its use. PVP-I gel forming solutions can circumvent this problem due to their higher viscosity and prolonged clearing time. Objective: Characterize the in vitro virucidal activity of long-acting PVP-I compositions developed using an in situ gel forming technology against the SARS-CoV-2 virus and test its safety using a rat model. Methods: We tested different dilutions of the PVP-I gel forming solution– full concentration, 90%, 50%, 28% and 9% of the original formulation concentration – at varying exposure times to assess virucidal activity against SARSCoV- 2 in VERO76 cells infected. Virucidal activity was recorded as the reduction of v.. View More»
  DOI: 10.35248/2161-0495.21.s18.002

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