Journal of Developing Drugs
Open Access

Dr, Department of Pharmaceutical Sciences, Punjab University, Chandigarh, India

Publications

• Research Article   
  Brain Targeting of Duloxetine Nanoemulsion: In vivo Pharmacokinetic and Bio-distribution Studies
  Author(s): Gurpreet Singh, Navleen Kaur Sidhu, Garima Khanna, Amita Sarwal* and Anurag Kuhad
  
  Duloxetine is a potent dual reuptake inhibitor of serotonin and norepinephrine receptors. Due to extensive first- pass metabolism, it has a major limitation of low and variable oral bioavailability. The present study aimed to develop a kinetically stable nanoemulsion using oil, surfactant, and co-surfactant for the better management of the major depressive disorder. The nanoemulsion was prepared by an aqueous titration method. The developed formulation was evaluated for pH, globule size, Transmission Electron Microscopy (TEM), iscosity, transmittance and further it was investigated for in vivo pharmacokinetic and bio-distribution study. According to the results of in vivo pharmacokinetic study in wistar rats, intranasal administration of duloxetine nanoemulsion in the brain had shorter Tmax compared with that of intravenous administration. The brain/blood .. View More»
  DOI: 10.35248/2329-6631.22.11.168

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