Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Lampe and Company Gmb H and Co. KG, Berlin, Germany
Research Article
COVID-19 Vaccination from First Dose to Booster: New Insights into the Frequency of Most Common Systemic Adverse Events and Possible Booster Nocebo Effects based on a Systematic Review
Author(s): Claudia Behrens, Maria Samii-Moghadam, Tatiana Gasperazzo, Anna M Gross, Jack Mitchell and Johannes B Lampe*
Background: Based on placebo data, it has been recently demonstrated that the frequencies of most common adverse events
(AEs) of COVID-19 vaccination are overestimated due to negative expectation bias of vaccine recipients (nocebo effect). Since
booster studies lack comparators, estimating the extent of the nocebo effect is difficult. We aimed to overcome this obstacle
through a systematic comparison of most common AE frequencies across vaccine doses (first, second, booster), age groups,
and vaccine vs. placebo arms.
Methods: We systematically assessed systemic AEs in approved COVID-19 vaccines according to the PRISMA guidelines. All
documents regarding COVID-19 vaccines with a booster dose authorized by the FDA (cutoff date 19 November 2021) were
systematically searched on PubMed and the FDA website. Solicited syste.. View More»
DOI:
10.35248/2167-0870.22.12.489