Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Department of Endocrinology, Russian University of People’s Friendship, Moscow, Russia

Publications

• Case Report   
  Priming with a GnRH Agonist Before Immature Oocyte Retrieval may Improve Maturity of Oocytes and Outcome in In Vitro Maturation (IVM) Cycle: A Case Report
  Author(s): Anna Smirnova*
  
  In the last several years the concept of using a gonadotropin releasing hormone agonist (GnRH-a) for triggering ovulation in patients treated by an antagonist protocol for IVF became almost a routine clinical practice. It may promote oocyte nuclear maturation, resumption of meiosis and cumulus expansion. Several studies reported the retrieval of more mature oocytes after GnRH-a, therefore it seems that this attempt could be beneficial in an in vitro maturation (IVM) oocyte cycle performed for fertility preservation in patients with malignancies but possible for other indication as polycystic ovarian syndrome patients. We presented a case of a patient needed fertility preservation that underwent 3 IVM cycles priming ovulation with a GnRH-a. Twelve oocytes were obtained, all of them matured 4.5 hours after incubation in maturation media. Fertilization rate after ICSI was 10/12 (83%). Si.. View More»
  DOI: 10.35248/2375-4508.21.9.228

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