Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Anne Katrine Toft-Kehler MD, PhD, Medical Specialist (ophthalmology) at UNION Therapeutics A/S Medical doctor with interest in ophthalmology and dermatology, drug development and strategy. Research experience within ophthalmology, neurology and inflammation. completed her post doctorate in the uear of 2010 form Kobenhavns Universitet-University of Copenhagen. worked as Medical Specialist (ophthalmology) form Union therapeutics A/S in the year 2019.
Research Article
Investigation of the Association between the Oral and the Gut Microbiome in
Glaucoma
Author(s): Anne Katrine Toft-Kehler, Jeppe Vibæk, Miriam Kolko* and Gus Gazzard
Objective: Glaucoma is characterized by a progressive degeneration of retinal ganglion cells (RGC) and their axons
leading to painless damage of the visual field and finally blindness. The exact pathophysiology of RGC loss remains
unknown.
Alterations in the microbiome may be linked to neurodegenerative conditions such as Alzheimer’s and Parkinson’s
diseases, possibly due to associated chronic low-grade inflammation. A recent study linked alterations in the oral
microbiome and glaucoma.
Methods: We investigated the microbiome of salivary and fecal samples in patients with normal tension glaucoma
(10), ocular hypertension (11) and controls (11) using a case-control design with 16S rDNA sequencing.
Results: For controls, but not the patient groups, salivary and fecal microbiome diver.. View More»
DOI:
10.35248/2155-9570.20.11.826