Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Pathology Research Core, Mayo Clinic, Rochester, MN 55905, USA
Research Article
Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas
Author(s): Hee Eun Lee, Lei Luo, Trynda Kroneman, Marie R Passow, Kristina M del Rosario, Michael R Christensen, Mary E Francis, John W O’Shaughnessy, Anthony J Blahnik, Ping Yang and Eunhee S Yi*
Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not
well known.
Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from
120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells,
CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the
stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells and B-cells
were correlated with patient’s overall survival (OS) using Cox proportional hazards analysis.
Results: Median age of patients was 69 years (range, 46-91 years) and 52 were male. Median numbers
(interquartile range) .. View More»
DOI:
10.35248/2155-9899.20.11.584