Journal of Applied Pharmacy
Open Access
ISSN: 1920-4159
+44 1300 500008
ISSN: 1920-4159
+44 1300 500008
Department of Basic Medical Sciences, Faculty of Pharmacy, Hajvery University, Lahore, Pakistan
Research
Hepatoprotective Activity of Foeniculum vulgare Against Paracetamol Induced Hepatotoxicity in Rabbit
Author(s): Tayyaba Nazir*, Lubna Shakir, Zaka-ur-Rahman, Komal Najam, Aqsa Choudhary, Nasira Saeed, Haroon-ur-Rasheed, Anam Nazir, Shawana Aslam and Arshia Batool Khanum
The hepatoprotective effects of a Foeniculum vulgare extract was determined in male rabbits (Oryctolagus cuniculus). The Foeniculum vulgare extract was used in different doses in Paracetamol induced toxicity in rabbits. Foeniculum vulgare seeds were obtained from market and identified by Punjab University. Extract was prepared by maceration method. Foeniculum vulgare seeds 100 gm were weighed after grinding then added in flask. 80% ethanol solution was added four times more than the weight of Foeniculum vulgare powder and then kept for 4 days on shaker and filtered through Whatman filter paper. Solvent extract was evaporated at temperature of 25°C. Extract powder was obtained. Powder extract 250 mg/kg/BW and 500 mg/kg/BW was filled in capsule of 2 & 0 size respectively. 16 rabbits, with an average age of 3-4 months, were ta.. View More»
DOI:
10.35248/2376-0354.20.12.270