Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
A.N. Belozersky Institute of Physical and Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
Mini Review
The Features of the Cytoplasmic Actins: Cytoskeletal Structures and Functional Activities
Author(s): VB Dugina, GS Shagieva, AS Shakhov and IB Alieva*
Two actin isoforms build the actin cytoskeleton in non-muscle cells: β-and γ-cytoplasmic actins (β- and γ-actins),
encoded by ACTB and ACTG1 genes respectively. They are ubiquitously expressed in the different cells in vivo and in vitro, and the b/γ-actin ratio depends on the cell type. Cytoplasmic actins are both essential for the cell survival,
but they perform various functions in the interphase and during cell division, as well as they play different roles in
neoplastic transformation. In this review, we briefly summarize the research results of recent years and describe the
features of the cytoplasmic actins: spatial organization in close connection with their functional activity during the
cell cycle... View More»
DOI:
10.35248/2155-9899.21.12.614