Virology & Mycology
Open Access

Department of Biochemistry and Biotechnology, Genetic Engineering Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, West Bengal, India

Biography

Dr.Asit Kumar Chakraborty was a molecular biologist experienced in bacteriology,protein purification, mammalian cell culture, plant tissue culture, retrovirology, gene therapy, gene transcription and drug discovery.

Publications

• Research   
  Corona Virus ORF1ab-Derived Nsp9 and Nsp10Non-Structural Proteins have Homologies to S8/S10 Ribosomal Proteins as well as RlmG/ ErmDrRNAMethyltransferasesand may Inhibit Host Mitoribosome Assembly and Protein Synthesis
  Author(s): Asit Kumar Chakraborty*
  
  Multi-Alignment method coupled with phylogenetic analysis we disclosed the Nsp9 and Nsp10 non-structural proteins of Corona Virus asrRNARlmH/K methyltransferases with similarities with bin recombinase and int-core integrase fold. Further, Nsp9 has similarities to S8 ribosomal protein and Nap10 has similarity to S10 ribosomal protein. Previously, we showed Nsp13, Nsp14, Nsp15 and Nsp16 are also different types of rRNARlmE/N and Cfr-like methyltransferases-ribonucleasewith RNA helicase domains. Two domains of Nsp13 astonishingly have similarities to ribosomal proteins L6 and L9. Taken together, Nsp9/10 and Nsp13-16 proteins could mimic host ribosome assembly and also could methylate rRNA of mitobibosome preventing mitochondrial protein synthesis and oxidative phosphorylation. Low ATP synthesis causes lowering blood pressure following coma but very ATP concentrati.. View More»
  DOI: 10.35248/2161-0517.20.09.186

  Abstract HTML PDF