Clinical Pediatrics: Open Access
Open Access

Department of Pediatrics, Faculty of Medicine, Fukuoka University, Japan

Publications

• Research Article   
  Predicting Very Severe Kawasaki Disease Who Does Not Respond to Initial Steroid Combination Therapy: A Prospective Cohort Study
  Author(s): Yukako Yoshikane*, Tatsuki Miyamoto, Junichi Hashimoto, Shinichi Hirose and Atsushi Ogawa
  
  Objective: Kawasaki Disease (KD) is an acute systemic vasculitis that can lead to ischemic heart disease resulting from coronary artery aneurysms. Intravenous Immunoglobulin (IVIG) resistance is a major risk factor for the development of Coronary Artery Lesions (CALs). Pulsed or non-pulsed steroids combination therapy as initial treatment for children with high risk KD was listed in the Japanese guideline in 2012. However, some patients with very severe KD do not improve even with the steroid combination therapy. The purpose of this study was to clarify the risk factors for severe KD patients who do not respond to the steroid combination therapy, and to confirm whether they can be predicted in the early stage. Methods: Forty hospitalized KD patients with high scores on all three Japanese prediction scoring systems and who received steroids with IVIG in initial treatment were prospecti.. View More»
  DOI: 10.35248/2572-0775.20.5.164

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