Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Ophthalmology, Tel Aviv University, Tel Aviv, Israel
Commentary
A Short Commentary on Understanding Inflammation Associated Ophth almic Pathologies: A Novel 3D Co-Culture Model of Monocyte-Myofibroblast Immunomodulation
Author(s): Avi Petroff*
The article titled “Understanding Inflammation-Associated Ophthalmic Pathologies: A Novel 3D Co-culture Model of Monocyte-Myofibroblast Immunomodulation” describes a simple 3D co-culture system that was used to model a human eye following glaucoma filtration surgery. Various specifications were implemented to the model to allow for a focused assessment on monocyte and myofibroblast immunomodulation of inflammatory cytokine signaling. However, the utility of such a model extends beyond the scope of the original paper, into areas of discovery such as pharmaceutical therapies and tissue-dependent models of inflammation and fibrosis. The original paper highlighted the importance of 3D and co-culture models for obtaining more comprehensive assessments of cellular responses to inflammatory stimuli, and thus the stress on these parameters should be maintained while other paramete.. View More»
DOI:
10.35248/2155-9570.22.13.923