Shagreen Health Life Sciences Ltd. Yenisehir Mah, Mehmet Nurdag Cad, Teras 2 Apt No: 28/26 Artuklu, Mardin, Turkey
Dr. Aziz Rodan Sarohan, is a reputed Doctor in the department of Obstetrics and Gynecology working in Baglar Private Hospital, Shagreen Health Life Sciences, Turkey. His area of interest includes Gynecology, Autoimmunity, Immunogenetics.
Review Article
Systemic Organ Involvement and Retinoid Signaling Disorder in COVID-19
Author(s): Aziz Rodan Sarohan*
Although more than a year has passed since the COVID-19 outbreak, the pathogenesis of the disease has not yet
been clearly explained. The way to develop effective vaccines and drugs against the disease depends on a clear
elucidation of the pathogenesis. Therefore, the underlying mechanism of COVID-19 pathogenesis has been one
of the most curious and studied topics since the beginning of the pandemic. Systemic organ involvement in
COVID-19 cannot be explained by viral tropism mediated by ACE2 and TMPRSS2. Many chronic, inflammatory,
and autoimmune diseases such as autism, dementia, and memory problems that emerged late after COVID-19 have
made the pathogenesis of COVID-19 even more mysterious. Our studies and current literature show that the main
problem in the pathogenesis of COVID-19 is retinol depletion and retinoid signal impairment. It is understood that
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DOI:
10.35248/igoa.21.6.145