Journal of Probiotics & Health
Open Access

Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam, Amsterdam, Netherlands

Biography

TNO Healthy Living aims to contribute to human health and wellbeing through development of novel strategies for prevention of (chronic) diseases, and providing individuals the means to make better and more healthy choices in nutrition and lifestyle. The human microbiome plays a key role in physiology, including immune, metabolic and neuronal processes. Alterations of the microbiome (or dysbiosis) greatly affects our health and long-term disease risk, relating  to important elements within TNO’s strategic innovation themes, e.g. Early Life, Prevention, Personalised Health, and Body-Brain.

Publications

• Research   
  The i-screen: A Versatile Preclinical Platform for Gut Microbiota Studies
  Author(s): Frank Schuren*, Valeria Agamennone, Bart Keijser, Edwin Abeln, Jos van der Vossen and Roy Montijn
  
  The gut microbiota is the complex community of microorganisms that inhabit the human intestine. Gut microbes participate in many aspects of human physiology, including health and disease. Food ingredients, drugs and other environmental factors can affect the gut microbiota, with possible consequences on human health. Progress in microbiome research has significantly stimulated and expanded the interest in technologies to study the potential of different products to modulate the gastro-intestinal ecosystem. In this context we have developed a method, called the i-screen, to evaluate the effects of compounds on the human gut microbiota. The i-screen is an in vitro system that allows the anaerobic cultivation of microorganisms obtained from fecal material, and therefore representative of the highly diverse colonic microbiota. By means of specific analyses, the effects .. View More»
  DOI: 10.35248/2329-8901.19.7.212

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