Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
ISSN: 2572-0775
Department of Paediatrics Obstetrics and Gynecology, University of Valencia, Valencia, Spain
Research Article
The sFlt-1/PlGF Ratio as Predictor of Adverse Maternal Outcome in Patients with Suspected Placental Insufficiency
Author(s): Alfredo Perales-Marin*, Francis Fernandez-de-la-Cruz, Marisa Martinez-Triguero, Amparo Alba-Redondo, Rogelio Monfort-Ortiz, Blanca Novillo-del-Alamo and Beatriz Marcos-Puig
Background: Angiogenic markers serve as crucial indicators of Adverse Pregnancy Outcomes (APRO). However, the variation in specific cut-off values used to assess APRO risk complicates their clinical utility. This study aims to identify the most predictive angiogenic marker or combination thereof for Adverse Maternal Outcomes (AMO), determining the optimal cut-off point for highest accuracy.
Methods: This observational retrospective cohort study utilized hospital medical records. We categorized singleton pregnancies (21-40 weeks gestation, n=60 each) into three groups based on sFlt-1/PlGF ratio levels: High (≥ 655), Intermediate (≥ 85 to <655) and Low (<85). Binary logistic regression was employed to identify the best predictors of AMO. Receiver Operating Characteristic (ROC) analysis was used to compare detection rates and.. View More»
DOI:
10.35248/2572-0775.24.09.277