Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Genomics, Helix Biogen Institute, Ogbomoso, Oyo State, Nigeria
Review Article
Steps and Tools Involved in In Silico Vaccine Design: A Review
Author(s): Boluwatife Olawale and Tifeola A. Oyewole*
In silico vaccine design is the computational biochemical preparation of vaccines. It is a modern approach to vaccine design and is very fast, inexpensive, effective and applicable to antigenically diverse pathogens when compared to the traditional method of vaccine design. The aim of this review is to explain the important steps, bioinformatics tools and immune-informatics approach useful in computational vaccine design. The databases and algorithms include National Centre for Biotechnology Information (NCBI), EMBOSS transeq, ANTIGENpro, AllerTOP, Toxinpred, NetCTL 1.2 server, IEDB MHC-II, and BCPred, which are respectively used for sequence retrieval and analysis, sequence translation, antigenicty, allergenicity and toxicity prediction, Cytotoxic T-Lymphocyte (CTL), Helper T-Lymphocyte (HTL) and B cell epitopes prediction. Additionally, this review gives a detail.. View More»
DOI:
10.35248/0974-276X.23.16.647