Journal of Antivirals & Antiretrovirals
Open Access

University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, United States

Biography

Brenda works at University of Hawaii Cancer Center, Honolulu, Hawaii, 96813, United States. His area of research interests includes Infectious diseases, virology. He /she has authored of many research articles/books in relevant areas.

Publications

• Research Article   
  siRNA-Inhibition of TIGAR Hypersensitizes Human Papillomavirus-Transformed Cells to Apoptosis Induced by Chemotherapy Drugs that Cause Oxidative Stress
  Author(s): Lacin Yapindi, Brenda Y. Hernandez and Robert Harrod*
  
  The high-risk subtype Human Papillomaviruses (hrHPVs), including HPV16, HPV18, HPV31, HPV33, and HPV45, infect and oncogenically transform epithelial cells and cause squamous cell carcinomas and adenocarcinomas associated with the development of cervical cancer and subsets of vulvar, vaginal, penile, and anogenital cancers, as well as head-and-neck oropharyngeal carcinomas which often have poor clinical prognoses. Many cancers have been shown to contain elevated levels of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR)-a glycolytic enzyme and antioxidant effector which frequently correlates with an aggressive tumor phenotype and serves as a determinant of therapy-resistance. We therefore tested whether siRNA-inhibition of TIGAR protein expression could sensitize HPV18-transformed HeLa cells to genotoxic chemotherapy agents (i.e., cisplatin, etoposide, .. View More»
  DOI: 10.35248/1948-5964.21.13.223

  Abstract HTML PDF