Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Medicine, University of Illinois College of Medicine, Chicago, IL, USA
Research
Immune-Modulating Effects of Mycobacteria
Author(s): Igor Gavin, Filbert Rosli and Bruce S. Gillis*
Several species of Mycobacterium have been identified as having the ability to modulate immune responses, even as heat-killed preparations. Our goal was to identify mycobacteria that could potentially act in a safe and non-toxic immune-modulating effect by promoting the production of specific chemokine and cytokine responses with a potential application for impacting the microbiome. We relied on the following Mycobacterium strains: M. smegmatis, M. agri, M. phlei, M. tokaiense, M. brumae, M. aurum, and M. obuense. M. smegmatis and M. agri were the most effective in inducing immune responses in cultured Peripheral Blood Mononuclear Cells (PBMC) manifested by extracellular productions of the cytokine IL-6, as well as the chemokines IL-8, MIP-1α and MIP-1β. Correlation anal.. View More»
DOI:
10.35248/2155-9899.22.13.673