Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence-Careggi University Hospital, Florence, Italy
Case Report
Primaquine-Induced Asymptomatic Methemoglobinemia Treated with N-Acetylcysteine: A Case Report
Author(s): Losso Lorenzo*, Bartalesi Filippo, Camiciottoli Gianna, Ciambellotti Lorenzo, Gambassi Francesco, Lagi Filippo, Mancarini Jessica, Mannaioni Guido and Ieri Alessandra
Introduction: Primaquine-induced methemoglobinemia is a rare pathological condition typically characterized by
mild-moderate symptoms driven by an increase in Methaemoglobin (MetHb) levels (normal value <1%), which can
lead to primaquine discontinuation, with major consequences for the management of the underlying disease.
Primaquine increases MetHb levels through a pro-oxidant environment promoted by its metabolites. To this aim, we
tested the hypothesis that N-Acetyl Cysteine (NAC), by acting as a reducing agent, could be safe and effective in the
treatment of primaquine-induced methemoglobinemia not requiring methylene blue treatment.
Methods: We report a 41-years-old woman affected by multiple sclerosis, in treatment with immune-modulatory
therapy, who was hospitalized for the management of Pneumocystis jirovecii.. View More»
DOI:
10.35248/2161-0495.23.13.529