Department of Pathology, Southeast Center for Integrated Metabolomics (SECIM), Clinical and Translational Science Institute, University of Florida, Gainesville, FL 32610, USA

Biography

Dr. Carolina E. Abrahan is a research scientist at the University of Florida (UF), specializing in analytical chemistry and mass spectrometry applications in biological research. She earned her Ph.D. in Analytical Chemistry from UF under the mentorship of Prof. James Winefordner, focusing on laser spectroscopy before transitioning to biological applications of mass spectrometry. DATACAMP In her role at UF, Dr. Abrahan contributes to various research projects, including studies on tryptophan metabolites in lupus-prone mice and the impact of oxybenzone-containing sunscreen on coral health and reproduction. She has co-authored several publications, such as: "Origin and Function of Tryptophan Metabolites Modulating CD4+ T Cells in Lupus-Prone Mice," published in iScience. GOOGLE SCHOLAR "Investigating the Impact of Oxybenzone-Containing Sunscreen on Coral Health and Reproduction," available on SSRN. GOOGLE SCHOLAR Dr. Abrahan's expertise in metabolomics and mass spectrometry supports UF's research initiatives, particularly in understanding metabolic processes and their implications in health and environmental sciences.

Publications

• Research Article   
  Modification of a Targeted Metabolomics Method Using Hydrophilic Interaction Liquid Chromatography-High Resolution Mass Spectrometry to Measure Nine Purines in Commercial Dog Foods
  Author(s): Chie Saito Ishii*, Karen C Scott, Carolina Abrahan, Joy G. Cagmat, Taylor A. Harmon, Yann Queau, Vincent Biourge, Timothy J. Garrett and Richard C Hill
  
  Urate is the third most common component of canine uroliths. Dogs with a genetic mutation or hepatic dysfunction are prone to forming urate uroliths because they excrete more poorly soluble urate as the end product of purine metabolism. Dietary purine restriction has been reported to reduce urinary urate concentrations in dogs, but the amount and types of purine in commercial diets have not been well documented. A previous targeted metabolomics method was modified to measure eleven purine metabolites in commercial dog foods. The method utilized hydrophilic interaction liquid chromatography-high-resolution tandem mass spectrometry with stable isotope-labeled internal standards. The within-day and between-day coefficient of variation of each purine metabolite concentration in quality control dog food samples averaged 6% (range: 4%-13%) and 15% (range: 11%-19%), respectively. Recoveries .. View More»
  DOI: 10.35248/2157-7064.23.14.539

  Abstract HTML PDF

Other relevant publications from this author

• A Proteolytic Regulator Controlling Chalcone Synthase Stability and Flavonoid Biosynthesis in Arabidopsis 

  The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair

  Photoreceptor sensitivity to oxidative stress can by regulated by non-redundant roles of PGC-1α and PGC-1β