Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Medical Laboratory Sciences, Universitatsklinikum Regensburg, Regensburg, Germany
Research Article
Evaluation of a Multimarker Panel in Chronic Heart Failure: A 10 Years Follow-Up
Author(s): Susanne Bauer*, Christina Strack, Ute Hubauer, Ekrem Ücer, Stefan Wallner, Andreas Luchner, Lars Maier and Carsten Jungbauer
Background: Chronic heart failure is a complex disease associated with various pathophysiological and biochemical
disorders. We assessed the 10 years prognostic role of a multimarker panel of markers for myocyte stress (GDF-15),
extra-cellular matrix remodeling (Galectin-3, mimecan, TIMP-1), inflammation (Galectin-3), myocyte injury (hs-TnT)
and angiogenesis (endostatin, IBP-4, IGF-BP-7, sFlt-1 and PLGF) head-to-head with the biochemical gold-standard
NT-proBNP.
Methods: Blood samplesfrom 149 patients with heart failure were analysed. After 10 years of follow-up (median
follow-up 104 months, IQR 43-117), data regarding rehospitalisation for chronic heart failure and all-cause-mortality
were acquired.
Results: Regarding Kaplan Meier analysis, all markers, dichotomized according to you denindex,.. View More»