Journal of Cancer Science and Research
Open Access

Department of Histology and Embryology, Faculty of Medicine, Gaziosmanpasa University, 60250,Tokat, Turkey

Publications

• Research Article   
  Vinorelbine Increases the Progression to Apoptosis in Hl-60 Acute Promyelocytic Leukemia Cell Line
  Author(s): Sevilcan Tuna Gazi*, Cem Gazi, Ercan Babur and Ayhan Bilir
  
  Background Vinorelbine is a semi-synthetic vinca alkaloid that has been employed both as a single agent and in combination, and has shown significant antitumor activity. Dexamethasone which acts on glucocorticoid and meperidine which acts on mu opioid receptors have pro-apoptotic and anti-proliferative effects. We investigated the effects of dexamethasone and meperidine on the cytotoxicity of vinorelbine on HL-60 human acute promyelocytic leukemia cell line. Methods The cytotoxic effects of vinorelbine alone and in combination with dexamethasone or meperidine were examined on the HL-60 cell line by performing plating efficacy, BrdU, caspase 3, bcl-2 immunocytochemistry and flow cytometry. Results We determined that vinorelbine inhibited cell proliferation and decreased the rate of sy.. View More»
  DOI: 10.35248/2576-1447.22.7.516

  Abstract HTML PDF