Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Operation Smile Italy Foundation, Smile House, Rome, Italy
Research Article
The Influence of Bolus of Methylprednisolone on Post-Orthognathic Surgery Symptoms: A Controlled Clinical Trial
Author(s): Amodeo Giulia*, Cerbelli Edoardo, Pisano Annalinda, Minieri Luciana and Scopelliti Domenico
Objective: Despite improvements in maxillary and mandibulary osteotomy, complications still result around 20%.
Post and intra-operative standard therapies, based on the use of betametasone and tranexamic acid, could help
to minimize the onset of side-effects. The aim of our study was to compare the role of a supplementary bolus of
methylprednisolone rather than the standard therapy in the onset of postoperative symptoms.
Methods: We enrolled 10 patients, affected by Class II and III Dentoskeletal, submitted to our institution for
maxillomandibular repositioning osteotomy between October 2020 and April 2021. Patients were divided in 2
groups as following; 5 patients (Group A) received standard therapy consisting in the administration of 4 mg of
Betamethasone, intraoperatively, and 1 gm of tranexamic acid in two administrations.. View More»
DOI:
10.35248/2167-0870.23.13.522