Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Biotechnology, Symphony Tech Biologics, Philadelphia, Pennsylvania, USA
Review Article
Immunology of the Liver in the Pathogenesis of Fibrosis, Cirrhosis, Autoimmune Disease and Viral Hepatitis
Author(s): Chaitrali Bakhale, Narendra Chirmule*, Prashant Singh, Puneet Gandhi, Sitabja Mukherjee and Santosh Kar
Liver is a crucial organ involved in many immunological processes, including clearance of pathogens, tolerance to
self-antigens and regulation of inflammation. It receives direct blood supply via the gut portal vein, which contains
dietary antigens and metabolites from resident microbiome. However, these processes can be disrupted by various
factors leading to liver diseases. In this review, we have summarized the recent developments in fibrosis, cirrhosis,
autoimmune diseases and infectious diseases. Fibrosis and cirrhosis are characterized by the accumulation of scar
tissue in the liver resulting from chronic inflammation and injury. The immune response to this injury involves
the activation of hepatic stellate cells, immune cells and cytokines, leading to inflammatory processes and fibrosis.
Autoimmune liver diseases, such as autoimmune hepatitis and p.. View More»
DOI:
10.35248/2471-9552.24.10.243