Journal of Applied Pharmacy
Open Access
ISSN: 1920-4159
+44 1300 500008
ISSN: 1920-4159
+44 1300 500008
Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India
He is affiliated to BRajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India. He is a recipient of many awards and grants for his valuable contributions and discoveries in major area of subject research. His publications includes Current Research and Development in Chemistry, Sequential Cytotoxicity: A Theory Examined Using 2, 6 diphenyl Piperidine-4-one scaffold, Comparative Standardization Study of Two Marketed Shatavari Churna Formulation etc.
Research Article
Hepatoprotective Effect of Ethanolic Extracts of Allophylus Cobbe (L.) Raeusch Leaves against Paracetamol Induced Hepatotoxicity in Rats
Author(s): Sandeep Chavan*, Remeth Dias and Chandrakant Magdum
Objective: Aim of the current investigation is to screen the hepatoprotective activity of the Ethanolic Extract of
Allophylus Cobbe (EEAC) leaves against Paracetamol (PCM) induced hepatotoxicity in rats.
Methods: EEAC was administered to the rats for 7 days (200 mg/kg and 400 mg/kg) and hepatotoxicity was induced
by administration of PCM (3 g/k day . After 24 h of toxicity induction, the blood samples were collected
by retro orbital plexus method and different serum and tissue biochemical parameters were analyzed. Livers of the
animals were isolated and were studied for histopathological changes. The extract treated animals were compared
with Silymarin (100 mg/kg).
Results: Treatment of animals with EEAC at 200 and 400 mg/kg showed dose dependant significant decrease in
Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruv.. View More»
DOI:
10.35248/1920-4159.21.13.300