ISSN: 2472-4971
Department of Pathology, Microbiology and Immunology, Nashville, Tennessee, USA
Dr. Shi is a gastrointestinal (GI)/liver pathologist. Her particular areas of interest are GI and pancreatic neuroendocrine tumors and pancreatic pathology. Her research interests include 1) Pathobiology of GI and pancreatic neuroendocrine tumors and 2) Identification of diagnostic, prognostic and therapeutic biomarkers for colorectal and pancreatic cancers In addition, she provide expertise in interpretation of histopathologic changes and immunohistochemical findings in animal models of GI and pancreatic diseases and in human GI and pancreatic diseases to collaborative scientists at Vanderbilt.
Research
Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine Tumors with Mesenteric Tumor Deposits
Author(s): Satya Das*, Chanjuan Shi, Tatsuki Koyama, Yi Huang, Raul Gonzalez, Kamran Idrees, Christina Edwards Bailey and Jordan Berlin
Objective: Well-differentiated small-intestinal neuroendocrine tumors (SI-NETs) tend to be biologically indolent.Despite this tendency, they have a predilection for metastasis. Peritoneal involvement is quite common as isunfortunately peritoneal carcinomatosis (PC). PC is a dreaded metastatic complication due to the significant morbidity it creates for patients as well as well as increasing their mortality risk. The risk factors for PC development in SI-NETs remain understudied; however, one such factor may be the presence of mesenteric tumor deposits (MTDs).
Methods: We performed a retrospective analysis on 208 well-differentiated SI-NET patient samples, the majority with mesenteric masses, from the pathology archives of Vanderbilt University Medical Center. We sought to explore whether MTD presence was associated with PC, what other patien.. View More»