Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Cell Signal Transduction, Medical School of Henan University, Henan, China
Research Article
Prognostic Analysis of PTEN Mutation in Endometrial Carcinoma
Author(s): Chaopeng Ye, Yuanqiao Ma, Qi Zhang, Wei Zhao* and Guoqing li
Purpose: Endometrial Carcinoma (EC) is recognized as one of the most common female reproductive system malignant
tumors. Great efforts have been made to improve the diagnosis and prognostic analysis of EC, however, more sensitive
prognostic evaluation system for EC remains to be established. The mutation status of PTEN and its association with clinical
characteristics, as well as its prognostic value in EC need to be evaluated.
Methods: TCGA dataset comprised of 526 EC cases were used to perform a comprehensive analysis of PTEN mutation.
Kaplan-Meier survival plot were performed to analyze the clinical significance of PTEN mutation. GO, KEGG pathway and
IPA network analysis were performed to identify the specific pathways for PTEN mutation patients. And the prognostic value
of PTEN mutation was further analyzed.
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DOI:
10.35248/2167-0870.22.S17.002